The third component of the complement (C3) is a marker of the risk of atherogenesis

V Capuano, T D'Arminio, GL Sala… - European Journal of …, 2006 - academic.oup.com
Aim The aim of this study was to assess the association between the third component of the
complement (C3) and other risk factors of coronary heart disease. Methods and results We …

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study

G Engström, B Hedblad, L Janzon, F Lindgärde - Diabetologia, 2005 - Springer
Aims/hypothesis Mice that are deficient for complement factor 3 (C3) have shown resistance
to weight gain, despite increased food intake. Cross-sectional studies of humans have …

Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk

CM Phillips, E Kesse-Guyot, N Ahluwalia, R McManus… - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome
(MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel …

Complement‐mediated chronic inflammation is associated with diabetic microvascular complication

T Fujita, S Hemmi, M Kajiwara, M Yabuki… - Diabetes/metabolism …, 2013 - Wiley Online Library
Background Chronic inflammation is characteristic of type 2 diabetes mellitus (T2DM).
Obesity‐activated adipocytes release adipocytokines, which induce the secretion of …

Metabolic impact on serum levels of complement component 3 in Japanese patients

I Ohsawa, H Inoshita, M Ishii, G Kusaba… - Journal of clinical …, 2010 - Wiley Online Library
The aim of this study was to explore the association between the serum concentration of
complement component 3 (C3) and a variety of metabolic parameters. The study involved …

Postprandial increase of complement component 3 in normolipidemic patients with coronary artery disease: effects of expanded-dose simvastatin

CJM Halkes, H Van Dijk, PPT De Jaegere… - … , and vascular biology, 2001 - Am Heart Assoc
Plasma concentrations of the third complement component (C3) predict the risk of
myocardial infarction. Because chylomicrons stimulate C3 production by adipocytes in vitro …

Complement C3 Is a Risk Factor for the Development of Diabetes: A Population-Based Cohort Study

G Engstrom, B Hedblad, KF Eriksson, L Janzon… - Diabetes, 2005 - Am Diabetes Assoc
Cross-sectional studies have reported strong correlations between plasma levels of
complement C3, insulin, and glucose. This prospective study explored whether elevated …

Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an …

A Muscari, S Antonelli, G Bianchi, G Cavrini… - Diabetes …, 2007 - Am Diabetes Assoc
OBJECTIVE—This study was performed to ascertain the relative relevance of some
inflammatory markers in insulin resistance. RESEARCH DESIGN AND METHODS—Four …

Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis

I Arias de la Rosa, P Font… - … in Chronic Disease, 2020 - journals.sagepub.com
Objective: To analyze the relationship between complement component 3 (C3) and the
prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases …

Plasma C3d levels and ischemic heart disease in type II diabetes

A Figueredo, JL Ibarra, J Bagazgoitia… - Diabetes …, 1993 - Am Diabetes Assoc
OBJECTIVE To test the hypothesis that the complement system may be activated in patients
with type II diabetes and CAD. RESEARCH DESIGN AND METHODS The plasma C3d …