Soluble CD14 and CD14 Variants, Other Inflammatory Markers, and Glucose Dysregulation in Older Adults: The Cardiovascular Health Study

SG Shitole, ML Biggs, AP Reiner, KJ Mukamal… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Experimental studies have implicated soluble (s) CD14, an effector of
lipopolysaccharide-induced inflammation, in insulin resistance, but its role in human …

Association of serum C3 levels with the risk of myocardial infarction

A Muscari, C Bozzoli, GM Puddu, Z Sangiorgi… - The American journal of …, 1995 - Elsevier
PURPOSE: Serum complement and IgA levels have been found to be retrospectively
associated with the presence of diffuse atherosclerosis. This study was performed to assess …

Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese

B Wang, Q Li, Y Jiang, Z Liu, L Zhong, R Luo… - Inflammation …, 2011 - Springer
Objective To compare association of complement C3 (C3) and high sensitive C-reactive
protein (hs-CRP) with insulin resistance. Subjects A total of 587 non-diabetic Chinese aged …

Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in …

G Széplaki, Z Prohászka, J Duba, S Rugonfalvi-Kiss… - Atherosclerosis, 2004 - Elsevier
Atherosclerosis is an inflammatory disease. The complement system plays an important role
in the atherosclerotic process. However, lesser data is available on the possible role of C3 …

Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis

WS Speidl, M Exner, J Amighi, SP Kastl… - European heart …, 2005 - academic.oup.com
Aims Complement activation occurs in atherosclerotic lesions, and particularly complement
component C5a exerts potent chemotactic and proinflammatory effects. However, it is yet …

Dual role of complement in adipose tissue

M Pattrick, J Luckett, L Yue, C Stover - Molecular immunology, 2009 - Elsevier
Once thought of as purely the body's chief energy store, adipose tissue and its constituent
adipocytes have emerged as both a metabolic entity and an endocrine one. Complement is …

Serum complement C3/C4 ratio, a novel marker for recurrent cardiovascular events

A Palikhe, J Sinisalo, M Seppänen, H Haario… - The American journal of …, 2007 - Elsevier
Acute coronary syndrome is an inflammatory disease, during which the complement
cascade is activated. We assessed the complement C3 and C4 concentration ratio (C3/C4 …

Up-regulation of the complement system in subcutaneous adipocytes from nonobese, hypertriglyceridemic subjects is associated with adipocyte insulin resistance

MMJ Van Greevenbroek, S Ghosh… - The Journal of …, 2012 - academic.oup.com
Background: Dysfunctional adipose tissue plays an important role in the etiology of the
metabolic syndrome, type 2 diabetes, and dyslipidemia. However, the molecular …

The complement system is dysfunctional in metabolic disease: Evidences in plasma and adipose tissue from obese and insulin resistant subjects

JM Moreno-Navarrete, JM Fernández-Real - Seminars in cell & …, 2019 - Elsevier
The relationship among chronic low-grade inflammation, insulin resistance and other
obesity-associated metabolic disturbances is increasingly recognized. The possible …

Relationship between serum complement and different lipid disorders

AL Pasqui, L Puccetti, G Bova, M Di Renzo… - Clinical and …, 2002 - Springer
Inflammatory and lipid factors share an important role in atherosclerosis. Recent studies
showed the concomitant presence and increase of complement components and lipid both …