C5aR and C3aR antagonists each inhibit diet‐induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

J Lim, A Iyer, JY Suen, V Seow, RC Reid… - The FASEB …, 2013 - Wiley Online Library
Mammalian survival depends on metabolizing nutrients, storing energy, and combating
infection. Complement activation in blood triggers energy‐depleting immune responses to …

A new effector of lipid metabolism: complement factor properdin

D Gauvreau, C Roy, FQ Tom, HL Lu, P Miegueu… - Molecular …, 2012 - Elsevier
BACKGROUND: The complement system is well known for its role in innate immunity via the
classical, the alternative and the lectin pathways, although recent investigations suggest …

Postprandial inflammation and endothelial dysfuction

A Alipour, JWF Elte, HCT Van Zaanen… - Biochemical Society …, 2007 - portlandpress.com
Postprandial hyperlipidaemia is a common metabolic disturbance in atherosclerosis. During
the postprandial phase, chylomicrons and their remnants can penetrate the intact …

Genetic contribution to C-reactive protein levels in severe obesity

G Faucher, F Guénard, L Bouchard, V Garneau… - Molecular Genetics and …, 2012 - Elsevier
Obese individuals are characterized by a chronic, low-grade inflammatory state. Increased
levels of C-reactive protein (CRP), a marker of inflammation, have been observed in …

High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26: 0) in whole blood are associated with metabolic syndrome in Japanese men

A Kume, T Miyazaki, Y Kitamura, K Oshida… - diabetes research and …, 2008 - Elsevier
OBJECTIVE: Hexacosanoic acid (C26: 0) is a saturated very long-chain fatty acid and high
levels of C26: 0 in red blood cells are reported to be closely related with risk factors of …

Specific macrophage subsets accumulate in human subcutaneous and omental fat depots during obesity

A Girón‐Ulloa, E González‐Domínguez… - … and Cell Biology, 2020 - Wiley Online Library
Obesity is a chronic inflammatory disease associated with adipose tissue macrophage
(ATM) activation. ATMs from lean mice contribute to tissue homeostasis by their M2‐oriented …

Relations of visceral and abdominal subcutaneous adipose tissue, body mass index, and waist circumference to serum concentrations of parameters of chronic …

I Schlecht, B Fischer, G Behrens, MF Leitzmann - Obesity facts, 2016 - karger.com
Background: Different measures of body fat composition may vary in their relations to
parameters of chronic inflammation. Methods: We assessed the relations of visceral (VAT) …

Lean body mass and creatine kinase are associated with reduced inflammation in obesity

SI Bekkelund, R Jorde - European journal of clinical …, 2017 - Wiley Online Library
Background Obesity is associated with inflammation, but the role of lean mass and creatine
kinase (CK) on the inflammatory process is less known. We investigated the associations …

[PDF][PDF] The anti-inflammatory and bioregulatory effects of habitual exercise in high-fat diet-induced obesity involve crown-like structures and MCP-1 in white adipose …

I Gálvez, M Dolores Hinchado… - Exercise Immunology …, 2023 - eir-isei.de
Macrophage accumulation in the adipose tissue and changes in their inflammatory
phenotype is a hallmark of obesity-induced inflammation, notably forming inflammatory …

Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor

B Memoli, A Procino, P Calabro… - American Journal …, 2007 - journals.physiology.org
Only few studies have been addressed to the presence and regulation of C-reactive protein
(CRP) gene expression in different districts of adipose tissue, and no study has investigated …