Hepatic fibrosis is a reversible pathological process, in which fibrotic tissue is excessively
deposited in the liver during the repair process that follows hepatic injury. Early prevention …

Hydroxysafflor yellow A (HSYA) was isolated from the dried flower of Carthamus tinctorius L.
which was extensively used in traditional Chinese medicine to treat cirrhosis. However, the …

Context: One approach to protect against liver fibrosis is the use of herb-derived natural
compounds, such as hydroxysafflor yellow A (HSYA). The antifibrosis effect of HYSA against …

Objective: To evaluate the effect of hydroxysafflor yellow A (HSYA) on thioacetamide-
induced liver fibrosis. Methods: Thioacetamide was administered to rats intraperitoneally in …

Hepatic stellate cells (HSCs) undergo activation during the development of liver fibrosis.
Transcription factor myocyte enhancer factor (MEF2) 2C plays a key role in this process. In …

Hydroxysafflor yellow A (HSYA), the main active natural constituent extracted from
Carthamus tinctorius L., has been widely used for the treatment of cerebrovascular and …

Hydroxysafflor yellow A (HSYA), a major constituent in the hydrophilic fraction of the
safflower plant, can retard the progress of hepatic fibrosis. However, the anti-inflammatory …

Background Liver fibrosis is a prevalent pathological process in chronic liver diseases
characterized by excessive extracellular matrix (ECM) deposition and abnormal …

AIM: To observe the protective effects of Xiaochaihu Decoction (XCHD) on carbon
tetrachloride (CCl4)-induced hepatic fibrosis (HF) in mice. METHODS: HF was induced in …

Treatment of liver fibrosis and cirrhosis remains a challenging field. Hepatocyte injury and
the activation of hepatic stellate cells are the 2 major events in the development of liver …