The balance of reactive oxygen species (ROS) and nitric oxide, the cell redox state, appears
to be important in the mechanisms of heart failure. This balance has significant impact on …

Adaptation of the heart to intrinsic and external stress involves complex modifications at the
molecular and cellular levels that lead to tissue remodeling, functional and metabolic …

Chronic heart failure is associated with pathophysiologic alterations in myocardial and
vascular function. Accompanying these changes are increased oxidative stress and …

Heart failure is characterized by neurohumoral alterations, such as activation of the
sympathetic nervous system, stimulation of the renin-angiotensin system, increased activity …

Significance: Heart failure (HF) results from poor heart function and is the leading cause of
death in Western society. Abnormalities of Ca2+ handling at the level of the ventricular …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Heart failure is the major cause of hospitalization, morbidity and mortality worldwide.
Previous experimental and clinical studies have suggested that there is an increased …

Despite advances in treatment, chronic congestive heart failure carries a poor prognosis and
remains a leading cause of cardiovascular death. Accumulating evidence suggests that …

Heart failure and many of the conditions that predispose to heart failure are associated with
oxidative stress. This is considered to be important in the pathophysiology of the condition …

For more than 10 years heart failure was regarded as a com-plex cascade of chronic
inflammatory reactions that cause gradual cardiac depression and the syndrome of heart …