Background Psoriasis is an immune-mediated disease characterized by aberrant epidermal
differentiation, surface scale formation, and marked cutaneous inflammation. To better …

Psoriasis is a chronic inflammatory skin disease characterized by abnormal epidermal
proliferation. Several studies have shown that skin-infiltrating activated T cells and cytokines …

Psoriasis has been considered an autoimmune, T cell-mediated disorder in which adaptive
immune responses predominate over those of non-antigen-specific innate immunity. To test …

Psoriasis is a chronic autoimmune skin disease that can often be triggered upon skin injury,
known as Koebner phenomenon. Type 1 interferons (IFNα and IFNβ), key cytokines that …

Psoriasis is a common immune-mediated disease resulting from altered cross-talk between
keratinocytes and immune cells. Previous transcriptomic studies have identified thousands …

Psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is
involved in many cellular processes, including activation of dendritic cells (DCs), antigen …

Background Psoriasis lesions are characterized by large-scale shifts in gene expression.
Mechanisms that underlie differentially expressed genes (DEGs), however, are not …

The epidermal phenotype as observed in psoriatic skin results from inflammation and
abnormal proliferation and terminal differentiation of keratinocytes. Mice deficient for …

Psoriasis is a common, immunologically mediated, inflammatory and hyperproliferative
disease of the skin and joints, with a multifactorial genetic basis. We earlier mapped …

Background Psoriasis vulgaris is an inflammatory immune‐mediated disease, with lesional
skin characterized by sharply demarcated, erythematous scaly plaques. Uninvolved …