Molecular mechanisms involved in hepatic steatosis and insulin resistance
T Matsuzaka, H Shimano - Journal of diabetes investigation, 2011 - Wiley Online Library
Increased hepatic lipid content is associated with hepatic as well as whole‐body insulin
resistance and is typical for individuals with type 2 diabetes mellitus. However, whether …
resistance and is typical for individuals with type 2 diabetes mellitus. However, whether …
[HTML][HTML] Signalling mechanisms linking hepatic glucose and lipid metabolism
MO Weickert, AFH Pfeiffer - Diabetologia, 2006 - Springer
Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin
resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation …
resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation …
[HTML][HTML] Hepatic triacylglycerol accumulation and insulin resistance
CA Nagle, EL Klett, RA Coleman - Journal of lipid research, 2009 - ASBMB
The association of hepatic steatosis with hepatic insulin resistance and type 2 diabetes has
prompted investigators to elucidate the underlying mechanism. In this review we focus on …
prompted investigators to elucidate the underlying mechanism. In this review we focus on …
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
FR Jornayvaz, AL Birkenfeld… - Proceedings of the …, 2011 - National Acad Sciences
Mice overexpressing acylCoA: diacylglycerol (DAG) acyltransferase 2 in the liver (Liv-
DGAT2) have been shown to have normal hepatic insulin responsiveness despite severe …
DGAT2) have been shown to have normal hepatic insulin responsiveness despite severe …
[HTML][HTML] Hepatic diacylglycerol-associated protein kinase Cε translocation links hepatic steatosis to hepatic insulin resistance in humans
KW Ter Horst, PW Gilijamse, RI Versteeg… - Cell reports, 2017 - cell.com
Hepatic lipid accumulation has been implicated in the development of insulin resistance, but
translational evidence in humans is limited. We investigated the relationship between liver …
translational evidence in humans is limited. We investigated the relationship between liver …
[HTML][HTML] Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance and
type 2 diabetes in humans. Ongoing research aims to clarify the mechanisms involved in this …
type 2 diabetes in humans. Ongoing research aims to clarify the mechanisms involved in this …
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
T Galbo, RJ Perry, MJ Jurczak… - Proceedings of the …, 2013 - National Acad Sciences
Hepatic insulin resistance is a principal component of type 2 diabetes, but the cellular and
molecular mechanisms responsible for its pathogenesis remain unknown. Recent studies …
molecular mechanisms responsible for its pathogenesis remain unknown. Recent studies …
Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum
The causal role of abdominal overweight/obesity, insulin resistance and type 2 diabetes
(T2D) on the risk of fatty liver disease (FLD) has robustly been proven. A consensus of …
(T2D) on the risk of fatty liver disease (FLD) has robustly been proven. A consensus of …
Dissociating fatty liver and diabetes
Z Sun, MA Lazar - Trends in Endocrinology & Metabolism, 2013 - cell.com
Fatty liver disease is epidemiologically associated with type 2 diabetes (T2D), leading to a
speculation of a reciprocal cause–effect relationship and a vicious cycle of pathology. Here …
speculation of a reciprocal cause–effect relationship and a vicious cycle of pathology. Here …
Causes and metabolic consequences of fatty liver
Type 2 diabetes and cardiovascular disease represent a serious threat to the health of the
population worldwide. Although overall adiposity and particularly visceral adiposity are …
population worldwide. Although overall adiposity and particularly visceral adiposity are …