Increased hepatic lipid content is associated with hepatic as well as whole‐body insulin
resistance and is typical for individuals with type 2 diabetes mellitus. However, whether …

Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin
resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation …

The association of hepatic steatosis with hepatic insulin resistance and type 2 diabetes has
prompted investigators to elucidate the underlying mechanism. In this review we focus on …

Mice overexpressing acylCoA: diacylglycerol (DAG) acyltransferase 2 in the liver (Liv-
DGAT2) have been shown to have normal hepatic insulin responsiveness despite severe …

Hepatic lipid accumulation has been implicated in the development of insulin resistance, but
translational evidence in humans is limited. We investigated the relationship between liver …

Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance and
type 2 diabetes in humans. Ongoing research aims to clarify the mechanisms involved in this …

Hepatic insulin resistance is a principal component of type 2 diabetes, but the cellular and
molecular mechanisms responsible for its pathogenesis remain unknown. Recent studies …

The causal role of abdominal overweight/obesity, insulin resistance and type 2 diabetes
(T2D) on the risk of fatty liver disease (FLD) has robustly been proven. A consensus of …

Fatty liver disease is epidemiologically associated with type 2 diabetes (T2D), leading to a
speculation of a reciprocal cause–effect relationship and a vicious cycle of pathology. Here …

Type 2 diabetes and cardiovascular disease represent a serious threat to the health of the
population worldwide. Although overall adiposity and particularly visceral adiposity are …