TRPM2 is a cation channel enabling influx of Na+ and Ca 2+, leading to depolarization and
increases in the cytosolic Ca 2+ concentration ([Ca 2+] i). It is widely expressed, eg in many …

The transient receptor potential melastatin-3 (TRPM3) channel belongs to the family of
transient receptor potential (TRP) cation channels that are expressed in a variety of tissues …

TRPM2 is a calcium-permeable nonselective cation channel that is opened by the binding of
ADP-ribose (ADPR) to a C-terminal nudix domain. Channel activity is further regulated by …

TRPM channels are a subgroup of the transient receptor potential (TRP) channel
superfamily whose members have important roles in cell proliferation and survival. TRPM2 …

Abstract TRPM2 is a Ca 2+-permeable non-selective cation channel that can be activated by
adenosine dinucleotides, hydrogen peroxide, or intracellular Ca 2+. The protein is …

TRPM2 (transient receptor potential channel, subfamily melastatin, member 2) is a Ca2+-
permeable non-selective cation channel activated by the binding of adenosine 5 …

Importance of the field: Oxidative stress, through production of reactive oxygen species,
triggers disturbance in intracellular calcium [Ca2+] i homeostasis, which has been identified …

Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein
family and, similarly to TRPM5, is Ca2+ sensitive and permeable for monovalent but not …

OBJECTIVE TRPM2 is a Ca2+-permeable nonselective cation channel activated by
adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by …

Like a number of other TRP channels, TRPM2 is a Ca2+-permeable non-selective cation
channel, the activity of which is regulated by intracellular and extracellular Ca2+. A unique …