The mechanism behind the inhibitory effect of isoflurane on angiotensin II-induced vascular contraction is different from that of sevoflurane
A Ishikawa, K Ogawa, Y Tokinaga… - Anesthesia & …, 2007 - journals.lww.com
BACKGROUND: Angiotensin II (Ang II)-induced vascular contraction is mediated both by a
Ca 2+-mediated signaling pathway and a Ca 2+ sensitization mechanism. We recently …
Ca 2+-mediated signaling pathway and a Ca 2+ sensitization mechanism. We recently …
Sevoflurane Inhibits Angiotensin II–induced, Protein Kinase C–mediated but Not Ca2+-elicited Contraction of Rat Aortic Smooth Muscle
J Yu, Y Tokinaga, K Ogawa, S Iwahashi… - The Journal of the …, 2004 - pubs.asahq.org
Background Whether volatile anesthetics attenuate angiotensin II-mediated vascular tone
has not been determined. The current study was designed to investigate the effects of …
has not been determined. The current study was designed to investigate the effects of …
Propofol attenuates angiotensin II-induced vasoconstriction by inhibiting Ca2+-dependent and PKC-mediated Ca2+ sensitization mechanisms
T Kuriyama, Y Tokinaga, K Tange, Y Kimoto… - Journal of …, 2012 - Springer
Abstract Purpose Angiotensin II (Ang II)-induced vascular contraction is mediated by Ca 2+-
dependent mechanisms and Ca 2+ sensitization mechanisms. The phosphorylation of …
dependent mechanisms and Ca 2+ sensitization mechanisms. The phosphorylation of …
The inhibitory effects of sevoflurane on angiotensin II-induced, p44/42 mitogen-activated protein kinase-mediated contraction of rat aortic smooth muscle
J Yu, K Mizumoto, Y Tokinaga, K Ogawa… - Anesthesia & …, 2005 - journals.lww.com
IMPLICATIONS: The present study demonstrates that sevoflurane can dose-dependently
inhibit both angiotensin II (Ang II)-induced contraction and p44/42 MAPK phosphorylation of …
inhibit both angiotensin II (Ang II)-induced contraction and p44/42 MAPK phosphorylation of …
Isoflurane Alters Angiotensin II–Induced Ca2+Mobilization in Aortic Smooth Muscle Cells from Hypertensive Rats: Implication of Cytoskeleton
E Samain, H Bouillier, C Rucker-Martin… - The Journal of the …, 2002 - pubs.asahq.org
Background Angiotensin II (AngII) is a potent vasoconstrictor involved in the short-term
control of arterial blood pressure. Isoflurane was reported to decrease vascular tone through …
control of arterial blood pressure. Isoflurane was reported to decrease vascular tone through …
Sevoflurane inhibits angiotensin II-induced Rho kinase-mediated contraction of vascular smooth muscle from spontaneously hypertensive rat
N Uematsu, K Ogawa, Y Tokinaga, K Tange… - Journal of …, 2011 - Springer
Abstract Purpose Angiotensin II (Ang II)-induced vasoconstriction is mediated by changes in
intracellular free Ca 2+ concentration ([Ca 2+] i) and myofilament Ca 2+ sensitivity. Protein …
intracellular free Ca 2+ concentration ([Ca 2+] i) and myofilament Ca 2+ sensitivity. Protein …
The vascular relaxing effects of sevoflurane and isoflurane are more important in hypertensive than in normotensive rats
J Yu, K Ogawa, Y Tokinaga… - Canadian Journal of …, 2004 - search.proquest.com
The vascular response to anesthetics is altered in hypertensive patients since the functional
and structural integrities of vascular smooth muscle and endothelium are deranged. The …
and structural integrities of vascular smooth muscle and endothelium are deranged. The …
Isoflurane-induced vasodilation: role of the α-adrenergic nervous system
DA Schwinn, RW McIntyre, JG Reves - Anesthesia & Analgesia, 1990 - journals.lww.com
Isoflurane is a potent systemic vasodilator. Because isoflurane vasodilation is clinically
significant, we sought to explore whether decreases in systemic vascular resistance caused …
significant, we sought to explore whether decreases in systemic vascular resistance caused …
Sevoflurane and isoflurane inhibit KCl-induced Class II phosphoinositide 3-kinase α subunit mediated vasoconstriction in rat aorta
S Yang, Q Wu, S Huang, Z Wang, F Qi - BMC anesthesiology, 2015 - Springer
Background Class II phosphoinositide 3-kinase α-isoform (PI3K-C2α) is involved in
regulating KCl-induced vascular smooth muscle contraction. The current study was to …
regulating KCl-induced vascular smooth muscle contraction. The current study was to …
Volatile anesthetics inhibit angiotensin II-induced vascular contraction by modulating myosin light chain phosphatase inhibiting protein, CPI-17 and regulatory subunit …
F Qi, K Ogawa, Y Tokinaga, N Uematsu… - Anesthesia & …, 2009 - journals.lww.com
BACKGROUND: Vascular contraction is regulated by myosin light chain (MLC)
phosphorylation. Inhibition of MLC phosphatase (MLCP) increases MLC phosphorylation for …
phosphorylation. Inhibition of MLC phosphatase (MLCP) increases MLC phosphorylation for …