An alternative allergen: adjuvant formulation potentiates the immunogenicity and reduces allergenicity of a novel subcutaneous immunotherapy product for treatment …

C Rask, L Lund, G Lund, B Heydenreich… - Clinical & …, 2012 - Wiley Online Library
Background Subcutaneous specific immunotherapy (SCIT) has proven sustained clinical
efficacy against allergy. The recommended regimen for SCIT is a gradual updosing over a …

[PDF][PDF] Safety and immunological changes during sublingual immunotherapy with standardized quality grass allergen tablets

HJ Malling, L Lund, H Ipsen… - Journal of Investigational …, 2006 - researchgate.net
Immunotherapy is the only treatment for allergy that has the potential to alter the natural
course of the disease. Sublingual immunotherapy for grass pollen-induced …

Specific subcutaneous immunotherapy with recombinant grass pollen allergens: first randomized dose‐ranging safety study

L Klimek, P Schendzielorz, R Pinol… - Clinical & Experimental …, 2012 - Wiley Online Library
Background Allergen‐specific immunotherapy (SIT) with native allergen extracts and
allergoids has been performed successfully for decades. Preliminary studies revealed the …

Allergenicity, immunogenicity and dose-relationship of three intact allergen vaccines and four allergoid vaccines for subcutaneous grass pollen immunotherapy

H Henmar, G Lund, L Lund, A Petersen… - Clinical & …, 2008 - academic.oup.com
Different vaccines containing intact allergens or chemically modified allergoids as active
ingredients are commercially available for specific immunotherapy. Allergoids are claimed to …

[PDF][PDF] Early improvement of patients' condition during allergen-specific subcutaneous immunotherapy with a high-dose hypoallergenic 6-grass pollen preparation

K Rajakulasingam - European annals of allergy and clinical …, 2012 - researchgate.net
Objective: A double-blind, placebo-controlled study was performed with 37 patients to
assess the efficacy as well as the safety of short-term pre-seasonal subcutaneous …

Implementation of pre‐seasonal sublingual immunotherapy with a five‐grass pollen tablet during optimal dosage assessment

F Horak, S Jaeger, M Worm, M Melac… - … & Experimental Allergy, 2009 - Wiley Online Library
Background The optimal dose (300IR) of a five‐grass pollen sublingual immunotherapy
tablet in terms of efficacy was previously demonstrated from the first pollen season …

Sublingual allergen immunotherapy: Immunological mechanisms and prospects for refined vaccine preparations

RE O'Hehir, A Sandrini, GP Anderson… - Current medicinal …, 2007 - ingentaconnect.com
Allergic diseases constitute a major health issue worldwide. Mainstay treatment constitutes
allergen avoidance and pharmacotherapy for symptom relief, but allergen immunotherapy …

Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study

T Quirino, E Iemoli, E Siciliani… - Clinical & …, 1996 - Wiley Online Library
Background Injective immunotherapy is a well‐known and recognized treatment for allergic
diseases, but its safety has been questioned during recent years. Alternative administration …

Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy

A Bufe, P Eberle, E Franke-Beckmann, J Funck… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Immunotherapy with the standardized quality grass tablet Grazax is
efficacious and well-tolerated in adult patients with rhinoconjunctivitis. Allergic asthma and …

Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy

G Senti, N Graf, S Haug, N Rüedi, S von Moos… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Subcutaneous allergen-specific immunotherapy is an effective treatment of
IgE-mediated allergies, but it requires repeated allergen injections with a risk of systemic …