Neural tube defects (NTDs) are among the most common structural birth defects observed in
humans. Mouse models provide an excellent experimental system to study the underlying …

Neural tube defects (NTDs) such as spina bifida and anencephaly are some of the most
common structural birth defects found in humans. These defects occur due to failures of …

During embryonic development, the central nervous system forms as the neural plate and
then rolls into a tube in a complex morphogenetic process known as neurulation. Neural …

Neural tube defects (NTDs) represent a common group of severe congenital malformations
that result from failure of neural tube closure during early development. Their etiology is …

The developing mammalian nervous system is subject to devastating congenital
malformations with clinical significance that extends into the billions of health care dollars …

The molecular requirements for neural tube closure are complex. This is illustrated by the
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …

We reviewed the genetic variants and strains of mice that are used as models for neural tube
defects (NTD) in humans. Over 40 genetic defects in mice cause obvious risk of NTD, but …

Neural tube defects (NTDs), including both spina bifida and anencephaly, are common
human congenital malformations that appear to be etiologically heterogeneous (Holmes et …

Neurulation, the early embryonic process of forming the presumptive brain and spinal cord,
is highly complex and involves hundreds of genes in multiple genetic pathways. Mice have …

Background Neural tube defects (NTDs) are debilitating birth defects involving the central
nervous system (CNS). Despite recent advances, NTDs represent the second most common …