Developing effective treatments for neurodegenerative diseases is one of the greatest
medical challenges of the 21st century. Although many of these clinical entities have been …

Alzheimer's disease (AD) and Parkinson's disease are the most common forms of age-
related neurodegenerative disorders. The pathogenesis of these and other …

Neurodegenerative diseases typically involve deposits of inclusion bodies that contain
abnormal aggregated proteins. Therefore, it has been suggested that protein aggregation is …

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …

In recent years, it has become increasingly clear that many neurodegenerative diseases
involve aggregation and deposition of misfolded proteins such as amyloid β, tau, α …

The distinct protein aggregates that are found in Alzheimer's, Parkinson's, Huntington's and
prion diseases seem to cause these disorders. Small intermediates—soluble oligomers—in …

A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …

▪ Abstract In the not-so-distant past, insoluble aggregated protein was considered as
uninteresting and bothersome as yesterday's trash. More recently, protein aggregates have …

The correlation between neurodegenerative disease and protein aggregation in the brain
has long been recognized, but a causal relationship has not been unequivocally …