Abstract Thyroxine 5′-deiodinase (5′ D) catalyses deiodination of the prohormone
thyroxine (T 4) to the metabolically active hormone 3, 5, 3′-tri-iodothyronine (T 3) …

Lactating rat mammary gland expresses a deiodinating activity that, on the basis of kinetic
characteristics, corresponds to the so-called 5′-deiodinase type I (D1). In the present study …

In the present study we have shown type II thyroxine 5′-deiodination (5′ D) in the rat
thymus. The enzyme activity was identified in crude extract homogenates by measuring the …

The negative feedback control of thyrotropin production by the anterior pituitary involves
local 5′-deiodination of l-thyroxine (L-T4) to the active thyroid hormone 3, 3′, 5-triiodo-l …

We investigated the regulation of type I iodothyronine 5'-deiodinase (5'-D) gene expression
by TSH and T3 in FRTL-5 rat thyroid cells. Northern blot analysis revealed that these cells …

Conversion of the prohormone T4 to the active hormone T3 is catalyzed by 5′-deiodinases,
enzymes that have not been purified. Previous studies have shown that modulating thyroid …

In the present study we have obtained several lines of evidence indicating the presence of
type II iodothyronine deiodinase (DII) in the mouse mammary gland. 5′-deiodinase activity …

Objective Local 5′-deiodination of l-thyroxine (T4) to active thyroid hormone 3, 3′, 5-tri-
iodothyronine (T3) catalyzed by the two 5′-deiodinase enzymes (D1 and D2) regulates …

A complementary DNA clone encoding the type I iodothyronine 5'-deiodinase (5'DI), which
converts T4 to T3, has been isolated recently. The 5'DI messenger RNA (mRNA) is most …

Type I 5′-deiodinase (5′ DI) is crucial for the generation of circulating 3, 5, 3′-
triiodothyronine (T3) and so is a major determinant of thyroid hormone action. Liver and …