Single-cell RNA sequencing (scRNA-seq) has allowed profiling cell types of the dorsal root
ganglia (DRG) and their transcriptional states in physiology and chronic pain. However, the …

The versatility of somatosensation arises from heterogenous human dorsal root ganglion
(DRG) neurons. The critical information to decipher their functions, ie, the soma …

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG)
neurons. However, soma transcriptomes of individual human DRG (hDRG) neurons–critical …

Different physical and chemical stimuli are detected by the peripheral sensory receptors of
dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent …

Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin,
muscles, bones, and viscera to detect touch and temperature as well as to mediate …

Peripheral nerve injury could lead to chronic neuropathic pain. Understanding
transcriptional changes induced by nerve injury could provide fundamental insights into the …

2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …

Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …

Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

Pain is one of the most significant causes of suffering and disability world-wide, and
arguably the most burdensome global health challenge. The growing number of patients …