Increased anxiety‐like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
J Blundell, K Tabuchi, MF Bolliger… - Genes, Brain and …, 2009 - Wiley Online Library
Neuroligins (NL) are postsynaptic cell adhesion molecules that are thought to specify
synapse properties. Previous studies showed that mutant mice carrying an autism …
synapse properties. Previous studies showed that mutant mice carrying an autism …
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
Multiple independent mutations in neuroligin genes were identified in patients with familial
autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that …
autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that …
Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice
KK Chadman, S Gong, ML Scattoni… - Autism …, 2008 - Wiley Online Library
Neuroligin‐3 is a member of the class of cell adhesion proteins that mediate synapse
development and have been implicated in autism. Mice with the human R451C mutation …
development and have been implicated in autism. Mice with the human R451C mutation …
Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number
Members of the neuroligin family of cell-adhesion proteins are found at excitatory and
inhibitory synapses and are mutated in some familial forms of autism spectrum disorders …
inhibitory synapses and are mutated in some familial forms of autism spectrum disorders …
[HTML][HTML] Neuroligin-4 regulates excitatory synaptic transmission in human neurons
The autism-associated synaptic-adhesion gene Neuroligin-4 (NLGN4) is poorly conserved
evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells. Here, we …
evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells. Here, we …
Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses
In human patients, loss-of-function mutations of the postsynaptic cell-adhesion molecule
neuroligin-4 were repeatedly identified as monogenetic causes of autism. In mice, neuroligin …
neuroligin-4 were repeatedly identified as monogenetic causes of autism. In mice, neuroligin …
Unique versus redundant functions of neuroligin genes in shaping excitatory and inhibitory synapse properties
Neuroligins are evolutionarily conserved postsynaptic cell adhesion molecules that interact
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
J Blundell, CA Blaiss, MR Etherton… - Journal of …, 2010 - Soc Neuroscience
Neuroligins (NLs) are a family of neural cell-adhesion molecules that are involved in
excitatory/inhibitory synapse specification. Multiple members of the NL family (including …
excitatory/inhibitory synapse specification. Multiple members of the NL family (including …
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
Mutations in many synaptic genes are associated with autism spectrum disorders (ASD),
suggesting that synaptic dysfunction is a key driver of ASD pathogenesis. Among these …
suggesting that synaptic dysfunction is a key driver of ASD pathogenesis. Among these …
Unusually rapid evolution of Neuroligin-4 in mice
MF Bolliger, J Pei, S Maxeiner… - Proceedings of the …, 2008 - National Acad Sciences
Neuroligins (NLs) are postsynaptic cell-adhesion molecules that are implicated in humans in
autism spectrum disorders because the genes encoding NL3 and NL4 are mutated in rare …
autism spectrum disorders because the genes encoding NL3 and NL4 are mutated in rare …