Abstract Background Cassia mimosoides Linn (CMD) is a traditional Chinese herb that
clears liver heat and dampness. It has been widely administered in clinical practice to treat …

Fructose is a key dietary factor in the development of nonalcoholic fatty liver disease
(NAFLD). Here we investigated whether WAY-362450 (WAY), a potent synthetic and orally …

Ethnopharmacology relevance The farnesoid X receptor (FXR) is a therapeutic target of for
the treatment of non-alcoholic fatty liver disease (NAFLD) owing to its regulatory role in lipid …

Farnesoid X receptor (FXR) has emerged as a promising therapeutic target for nonalcoholic
steatohepatitis (NASH) because of its tightly interwoven relationship with bile acid …

Background Gypenosides (Gyps), the major botanical component of Gynostemma
pentaphyllum, was found to up-regulate the farnesoid X receptor (FXR) in a mouse model of …

The farnesoid X receptor (FXR) plays a critical role in the regulation of lipid and bile acid
(BA) homeostasis. Hepatic FXR loss results in lipid and BA accumulation, and progression …

Farnesoid X receptor (FXR) agonist obeticholic acid (OCA) has emerged as a potential
therapy for nonalcoholic fatty liver disease (NAFLD). However, the side effects of OCA may …

BACKGROUND/AIMS: The farnesoid X receptor (FXR) is a member of the nuclear hormone
receptor superfamily, which plays an essential role in the regulation of enterohepatic …

Background and Purpose The molecular mechanism for the pathogenesis of nonalcoholic
fatty liver disease (NAFLD) remains elusive. Both farnesoid X receptor (FXR) signalling and …

Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The incidence
of NAFLD has increased steadily due to its close association with the global epidemic of …