Bim is a suppressor of Myc-induced mouse B cell leukemia
A Egle, AW Harris, P Bouillet… - Proceedings of the …, 2004 - National Acad Sciences
Impaired apoptosis is now recognized to be central to tumor development. Bcl2, activated by
chromosomal translocation in human follicular lymphoma, promotes oncogenesis by …
chromosomal translocation in human follicular lymphoma, promotes oncogenesis by …
MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation
LA O'Reilly, EA Kruse, H Puthalakath… - The Journal of …, 2009 - journals.aai.org
Survival and death of lymphocytes are regulated by the balance between pro-and
antiapoptotic members of the Bcl-2 family; this is coordinated with the control of cell cycling …
antiapoptotic members of the Bcl-2 family; this is coordinated with the control of cell cycling …
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation–induced apoptosis and deletion of autoreactive B cells
A Enders, P Bouillet, H Puthalakath, Y Xu… - The Journal of …, 2003 - rupress.org
During development, the stochastic process assembling the genes encoding antigen
receptors invariably generates B and T lymphocytes that can recognize self-antigens …
receptors invariably generates B and T lymphocytes that can recognize self-antigens …
Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors
T Shinjyo, R Kuribara, T Inukai, H Hosoi… - … and cellular biology, 2001 - Taylor & Francis
Two distinct signaling pathways regulate the survival of interleukin-3 (IL-3)-dependent
hematopoietic progenitors. One originates from the membrane-proximal portion of the …
hematopoietic progenitors. One originates from the membrane-proximal portion of the …
Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer
Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
P Bouillet, D Metcalf, DCS Huang, DM Tarlinton… - Science, 1999 - science.org
Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share
only the BH3 domain with this family. Gene targeting in mice revealed important …
only the BH3 domain with this family. Gene targeting in mice revealed important …
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
H Harada, B Quearry, A Ruiz-Vela… - Proceedings of the …, 2004 - National Acad Sciences
The “BH3-only” proapoptotic BCL-2 family members initiate the intrinsic apoptotic pathway.
A small interfering RNA knockdown of BIM confirms this BH3-only member is important for …
A small interfering RNA knockdown of BIM confirms this BH3-only member is important for …
Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim
P Bouillet, LC Zhang, DCS Huang, GC Webb… - Mammalian …, 2001 - Springer
Bim is a proapoptotic protein of the Bcl-2 family that shares only the short BH3 domain with
other members. It has three isoforms, apparently produced by alternative splicing. The …
other members. It has three isoforms, apparently produced by alternative splicing. The …
BH3-only protein BIM: an emerging target in chemotherapy
BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …
Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering
E Sandalova, CH Wei, MG Masucci… - Proceedings of the …, 2004 - National Acad Sciences
Bim, a proapoptotic BH3-only member of the Bcl-2 protein family, is required for central and
peripheral deletion of T lymphocytes. Mechanisms regulating Bim activity in T cells remain …
peripheral deletion of T lymphocytes. Mechanisms regulating Bim activity in T cells remain …