Human embryonic stem cell–derived mesenchymal stromal cells suppress inflammation in mouse models of rheumatoid arthritis and lung fibrosis by regulating T-cell …
Y Zhong, Y Zhu, X Hu, L Zhang, J Xu, Q Wang, J Liu - Cytotherapy, 2024 - Elsevier
Background aims Rheumatoid arthritis (RA) is characterized by an overactive immune
system, with limited treatment options beyond immunosuppressive drugs or biological …
system, with limited treatment options beyond immunosuppressive drugs or biological …
[HTML][HTML] Mesenchymal stem cell-based therapy for rheumatoid arthritis
M Sarsenova, A Issabekova, S Abisheva… - International journal of …, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …
[HTML][HTML] Clinical-grade human embryonic stem cell-derived mesenchymal stromal cells ameliorate the progression of osteoarthritis in a rat model
D Xing, K Wang, J Wu, Y Zhao, W Liu, JJ Li, T Gao… - Molecules, 2021 - mdpi.com
Mesenchymalstem cell (MSC)-based therapy is being increasingly explored in preclinical
and clinical studies as a regenerative method for treating osteoarthritis (OA). However, the …
and clinical studies as a regenerative method for treating osteoarthritis (OA). However, the …
[HTML][HTML] Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced immunomodulatory properties
SH Neo, Z Her, R Othman, CA Tee, LC Ong… - Stem Cell Research & …, 2023 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) have broad potential as a cell
therapy including for the treatment of drug-resistant inflammatory conditions with abnormal T …
therapy including for the treatment of drug-resistant inflammatory conditions with abnormal T …
Mesenchymal stem cells regulate the innate and adaptive immune responses dampening arthritis progression
RA Contreras, FE Figueroa, F Djouad… - Stem Cells …, 2016 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells that are able to immunomodulate
cells from both the innate and the adaptive immune systems promoting an anti‐inflammatory …
cells from both the innate and the adaptive immune systems promoting an anti‐inflammatory …
Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis
F Mao, WR Xu, H Qian, W Zhu, YM Yan, QX Shao… - Inflammation …, 2010 - Springer
Objective The objective of this study was to investigate the efficacy of mesenchymal stem
cell (MSC) in the treatment of arthritis. Methods Mesenchymal stem cells were injected …
cell (MSC) in the treatment of arthritis. Methods Mesenchymal stem cells were injected …
Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis
A Papadopoulou, M Yiangou, E Athanasiou… - Annals of the …, 2012 - ard.bmj.com
Objective The role of mesenchymal stem cells (MSC) in experimental arthritis is undoubtedly
conflicting. This study explored the effect of bone marrow-derived MSC in previously …
conflicting. This study explored the effect of bone marrow-derived MSC in previously …
[HTML][HTML] Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology
M Maumus, D Guérit, K Toupet, C Jorgensen… - Stem cell research & …, 2011 - Springer
Growing knowledge on the biology of mesenchymal stem cells (MSCs) has provided new
insights into their potential clinical applications, particularly for rheumatologic disorders …
insights into their potential clinical applications, particularly for rheumatologic disorders …
Interactions of mesenchymal stromal/stem cells and immune cells following MSC-based therapeutic approaches in rheumatoid arthritis
Rheumatoid arthritis (RA) is considered to be a degenerative and progressive autoimmune
disorder. Although several medicinal regimens are used to treat RA, potential adverse …
disorder. Although several medicinal regimens are used to treat RA, potential adverse …
Evaluation of the therapeutic efficacy of human bone marrow mesenchymal stem cells with COX-2 silence and TGF-β3 overexpression in rabbits with antigen-induced …
T He, S Sun - Experimental Cell Research, 2022 - Elsevier
Abstract Objective Mesenchymal stem cells (MSCs), especially genetically modified MSCs,
have become a promising therapeutic approach for the treatment of rheumatoid arthritis (RA) …
have become a promising therapeutic approach for the treatment of rheumatoid arthritis (RA) …