Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
Objective Activation of metabotropic glutamate receptor 5 (mGluR5) has neuroprotective
properties in vitro and has been reported to limit postischemic lesion volume in vivo …
properties in vitro and has been reported to limit postischemic lesion volume in vivo …
Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …
Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
Microglial-related factors have been implicated in the signaling cascades that contribute to
neuronal cell death in various neurodegenerative disorders. Thus, strategies that reduce …
neuronal cell death in various neurodegenerative disorders. Thus, strategies that reduce …
Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury
A Mukhin, L Fan, AI Faden - Journal of Neuroscience, 1996 - Soc Neuroscience
The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
Background Traumatic brain injury initiates biochemical processes that lead to secondary
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …
Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental …
Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …
contributes to chronic neurodegeneration and loss of neurological function. Selective …
Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats
JW Wang, HD Wang, ZX Cong, XS Zhang… - Biochemical and …, 2013 - Elsevier
A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …
Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury
JW Wang, HD Wang, WZ Zhong, N Li, ZX Cong - Brain research, 2012 - Elsevier
Traumatic brain injury (TBI)-released excessive glutamate resulted in the activation of
glutamate receptors including the metabotropic glutamate receptor 5 (mGluR5). To …
glutamate receptors including the metabotropic glutamate receptor 5 (mGluR5). To …
Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma
AI Faden, DM O'Leary, L Fan, W Bao, PGM Mullins… - Experimental …, 2001 - Elsevier
The effects of selective blockade of group I metabotropic glutamate receptor subtype 1
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …
Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury
SK Agrawal, E Theriault, MG Fehlings - Journal of neurotrauma, 1998 - liebertpub.com
Metabotropic glutamate receptors (mGluRs) participate in glutamate neural transmission, but
their role in the pathophysiology of spinal cord injury (SCI) has not been explored …
their role in the pathophysiology of spinal cord injury (SCI) has not been explored …
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