Objective Activation of metabotropic glutamate receptor 5 (mGluR5) has neuroprotective
properties in vitro and has been reported to limit postischemic lesion volume in vivo …

The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and
neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been …

Microglial-related factors have been implicated in the signaling cascades that contribute to
neuronal cell death in various neurodegenerative disorders. Thus, strategies that reduce …

The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …

Background Traumatic brain injury initiates biochemical processes that lead to secondary
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …

Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …

A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …

Traumatic brain injury (TBI)-released excessive glutamate resulted in the activation of
glutamate receptors including the metabotropic glutamate receptor 5 (mGluR5). To …

The effects of selective blockade of group I metabotropic glutamate receptor subtype 1
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …

Metabotropic glutamate receptors (mGluRs) participate in glutamate neural transmission, but
their role in the pathophysiology of spinal cord injury (SCI) has not been explored …