Numerous obesity loci have been identified using genome-wide association studies. A UK
study indicated that physical activity may attenuate the cumulative effect of 12 of these loci …

Physical activity (PA) may modify the genetic effects that give rise to increased risk of
obesity. To identify adiposity loci whose effects are modified by PA, we performed genome …

Background We have previously shown that multiple genetic loci identified by genome-wide
association studies (GWAS) increase the susceptibility to obesity in a cumulative manner. It …

Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci
to be associated with body mass index (BMI) and risk of obesity. Genetic effects can differ …

The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity
and obesity-related morbidities remains unknown. We explored how the interaction between …

Physical activity (PA) has been shown to reduce the impact of FTO variation and obesity
genetic risk scores (GRS) on BMI. We examined this interaction using a quantitative …

Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …

Obesity is a worldwide health problem that is closely linked to many metabolic disorders.
Regular physical exercise has been found to attenuate the genetic predisposition to obesity …

Obesity is highly heritable. Genetic variants showing robust associations with obesity traits
have been identified through genome-wide association studies. We investigated whether a …

Background/Objectives Recent large-scale genome-wide association studies have identified
multiple loci robustly associated with BMI, predominantly in European ancestry (EA) …