The juxtaglomerular apparatus (JGA) is a specialized contact region between the
glomerulus and the cortical thick ascending limb that plays an active role in the maintenance …

Gap junction intercellular communication (GJIC) plays a fundamental role in mediating
intercellular signals and coordinating multicellular behavior in various tissues and organs …

Glomerular mesangial cells (MCs) are specialized vascular smooth muscle cells that play a
critical role in the control of glomerular hemodynamics. One of the intriguing features of MCs …

ATP release from macula densa (MD) cells into the interstitium of the juxtaglomerular (JG)
apparatus (JGA) is an integral component of the tubuloglomerular feedback (TGF) …

Recent evidence obtained in rodents indicates that gap junctions in the juxtaglomerular
apparatus play an important role in the control of renin-producing cells and in …

In the adult kidney, renin-producing cells are typically located in the walls of afferent
arterioles at the transition into the glomerular capillary network. The mechanisms that are …

The molecular mechanisms with which the juxtaglomerular apparatus accomplishes its twin
functions, acute regulation of glomerular blood flow and secretion of renin, are still not …

The juxtaglomerular apparatus (JGA) consists of a tubular component, the macula densa
(MD), attached to a vascular component consisting of the afferent and efferent arterioles and …

Role of mesangial cells and gap junctions in tubuloglomerular feedback. Background
Tubuloglomerular feedback (TGF) is a process whereby the resistance of the afferent …

A change in intracellular Ca2+ is considered to be the common final signaling pathway
through which renin secretion is governed. Therefore, information relating to the generation …