Publisher Summary This chapter describes the cerebral vascular dysregulation in the
ischemic brain. Cerebral ischemia produces profound alterations of the major control …

Recent studies showed that spreading depolarizations (SDs) occurs abundantly in patients
following ischemic stroke and experimental evidence suggests that SDs recruit tissue at risk …

Cortical spreading depression (CSD) and depolarization waves are associated with
dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells …

Tissue responses to ischemia influx into neurons. The gating of glutamate receptor–
activated channels effectively achieves membrane shunting, which spreads in waves …

Objective Delayed ischemic neurological deficit (DIND) contributes to poor outcome in
subarachnoid hemorrhage (SAH) patients. Because there is continuing uncertainty as to …

Abstract 'Neuroprotection'is a term used to describe the putative effect of interventions
protecting the brain from pathological damage. In occlusive stroke, the concept of …

The effect of peri-infarct depolarizations on ischaemic injury was studied in rats submitted to
3 h occlusion of the left middle cerebral artery (MCA). The number of depolarizations varied …

Stroke is a devastating neurovascular disease with limited therapeutic options. The
pathogenesis of stroke involves complex interrelated molecular mechanisms including …

Background and Purpose—The role of SKCa and IKCa channels in myogenic tone and
endothelium-derived hyperpolarizing factor (EDHF) responsiveness was investigated under …

The term spreading depolarization describes a wave in the gray matter of the central
nervous system characterized by swelling of neurons, distortion of dendritic spines, a large …