For decades mitochondria have been considered static round-shaped organelles in charge
of energy production. In contrast, they are highly dynamic cellular components that undergo …

Background Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and
is characterized by progressive memory loss and cognitive impairment. Our understanding …

Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and
“adipose saccules” in the brain of his diseased patient Auguste Deter. The …

Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). In
particular, complex I impairment and subsequent oxidative stress have been widely …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects a
staggering percentage of the aging population and causes memory loss and cognitive …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

In the past decade, the genetic causes underlying familial forms of many neurodegenerative
disorders, such as Huntington's disease, Parkinson's disease, Alzheimer's disease …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …