Introduction• Age and AD related mitochondrial changes in brain and peripheral tissues•
Effect of APP accumulation on mitochondrial function• Mitochondria as a target and mediator …

Recent structural and functional studies of mitochondria have revealed that abnormalities in
mitochondria may lead to mitochondrial dysfunction in aged individuals and those with …

Significance: Synaptic degeneration, an early pathological feature in Alzheimer's disease
(AD), is closely correlated to impaired cognitive function and memory loss. Recent studies …

Mitochondria are dynamic organelles that undergo continuous fission and fusion, which
could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well …

Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular
physiology. They are responsible for producing the majority of a cell's ATP, thus supplying …

Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Mitochondrial dysfunction is involved in Alzheimer's disease (AD) pathogenesis.
Mitochondria have their own genetic material; however, most of their proteins (∼ 99%) are …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …

Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears
that neuronal homeostasis depends on high-fidelity mitochondria, in particular …