Pathological and therapeutic advances in Parkinson's disease: mitochondria in the interplay

P Naren, A Cholkar, S Kamble, SS Khan… - Journal of …, 2023 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative illness majorly
affecting the population between the ages of 55 to 65 years. Progressive dopaminergic …

Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

X Zhu, G Perry, MA Smith… - Journal of Alzheimer's …, 2013 - content.iospress.com
Mitochondrial dysfunction is one of the most early and prominent features in vulnerable
neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that …

Alterations in mitochondrial quality control in Alzheimer's disease

Q Cai, P Tammineni - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Mitochondrial dysfunction is one of the earliest and most prominent features in the brains of
Alzheimer's disease (AD) patients. Recent studies suggest that mitochondrial dysfunction …

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

IW Weidling, RH Swerdlow - Experimental neurology, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive brain disorder characterized by memory loss and
the accumulation of two insoluble protein aggregates, tau neurofibrillary tangles and beta …

Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

A Eckert, K Schmitt, J Götz - Alzheimer's research & therapy, 2011 - Springer
The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

JM Perez Ortiz, RH Swerdlow - British journal of pharmacology, 2019 - Wiley Online Library
Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …

Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress

A Jurcau - International journal of molecular sciences, 2021 - mdpi.com
As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

Mitochondrial function and abnormalities implicated in the pathogenesis of ASD

FJ Castora - Progress in Neuro-Psychopharmacology and …, 2019 - Elsevier
Mitochondria are the powerhouse that generate over 90% of the ATP produced in cells. In
addition to its role in energy production, the mitochondrion also plays a major role in …

Role of mitochondrial amyloid-β in Alzheimer's disease

JX Chen, SS Yan - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Abnormalities in
mitochondrial properties include impaired energy metabolism, defects in key respiratory …

Mitochondrial dysfunction: cause and consequence of Alzheimer's disease

K Friedland-Leuner, C Stockburger, I Denzer… - Progress in molecular …, 2014 - Elsevier
The etiology of common, nonfamiliar late-onset Alzheimer's disease (LOAD) is only partly
understood and seems to be extremely complex including many genetic and environmental …