Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the
signaling pathways governing NFκB regulation and function in the brain are poorly …

J. Neurochem.(2010) 113, 389–401. Abstract Alzheimer's disease (AD), a progressive
neurodegenerative disease characterized by the accumulation of amyloid‐β protein and …

Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …

Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

The importance of the complement system in Alzheimer's disease (AD) pathogenesis has
been emphasized through recent genome wide association studies. However, the cellular …

Background The linkages between neuroinflammation and Alzheimer's disease (AD)
pathogenesis are well established. What is not, however, is how specific immune pathways …

In this issue of Neuron, Chakrabarty et al.(2015) and Guillot-Sestier et al.(2015) reveal that
the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive …