Introduction The secreted frizzled-related protein 1 (SFRP1) gene, as a Wnt signaling
modulator, is frequently inactivated by promoter methylation in many tumors including …

BACKGROUND. The secreted frizzled‐related protein 1 gene (SFRP1) encodes a Wnt/β‐
catenin signaling antagonist and frequently is inactivated by promoter methylation in many …

AIM: To identify the methylation of secreted frizzled-related protein 1 (SFRP1) in gastric
cancer and to investigate the aberrant expression of SFRP1 and its correlation with the …

Wnt signaling is believed to be an important contributor to tumor development and has been
reported to be modulated by secreted frizzled-related proteins (SFRP). Nevertheless, the …

Objective: Our aim of the study was to investigate the expression level and methylation
status of the secreted frizzled-related protein 2 in esophageal squamous cell carcinoma and …

Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in human cancers.
The secreted frizzled‐related proteins (SFRPs) function as negative regulators of Wnt …

Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular
carcinoma (HCC). The secreted frizzled‐related proteins (SFRPs) function as negative …

AIM: To investigate the expression and methylation status of the secreted frizzled-related
protein 2 (SFRP2) in esophageal squamous cell carcinoma (ESCC) and explore its role in …

Results A significant decrease in the expression of SFRP1 and SFRP5 was observed in
gastric cancer compared with corresponding normal gastric tissues. The SFRP1 gene was …

Secreted Frizzled-related protein 1 (sFRP1), as one of most important Wnt antagonists, is
frequently silenced by promoter hypermethylation in many types of tumor, including …