AIM: To investigate the molecular mechanisms of berberine inhibition of hepatic
gluconeogenesis in a diabetic rat model. METHODS: The 40 rats were randomly divided into …

Berberine (BER), a natural product and active ingredient of genera Berberis and Coptis, has
been demonstrated to possess anti-diabetic activities. However, the poor bioavailability of …

Context Berberine is an alkaloid that possesses various pharmacologic effects. Objective To
explore the mechanism of berberine to improve insulin sensitivity in fructose-fed mice …

1) Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-
Sen University, Guangzhou 510006, China 2) Chengdu Military General Hospital, Chengdu …

Berberine (BBR) is a compound originally identified in a Chinese herbal medicine
Huanglian (Coptis chinensis French). It improves glucose metabolism in type 2 diabetic …

The effects of hormonal and dietary stimuli on hepatic glucose and lipid homeostasis include
regulation of gene expression. Berberine, an effective compound in certain Chinese …

Dysregulated glucagon drives hyperfunction in hepatic glucose output, which is the main
cause of persistent hyperglycemia in type 2 diabetes. Berberine (Zhang et al., 2010) has …

Purpose Activation of the hypothalamus-pituitary-adrenal (HPA) axis pathway is closely
related to insulin resistance (IR), glucose, and lipid metabolism disorders in type 2 diabetes …

Background Berberine is known to improve glucose and lipid metabolism disorders, but it
poorly absorbed into the blood stream from the gut. Therefore, the exact underlying …

Berberine is one of the main alkaloids of Rhizoma coptidis, proven to have anti-diabetic
potentials through activation of AMP activated protein kinase (AMPK) in liver and muscle …