The present invention provides novel human Small nuclear ribonucleoprotein (snRNP) Sm
proteins (collectively called HSMP) and polynucleotides which identify and encode HSMP …

Anti‐Sm antibodies from a patient with systemic lupus erythematosus (SLE) were used to
isolate cDNA clones encoding the snRNP‐associated protein N from a rat brain derived …

Mutations in the gene encoding the survival of motor neurons protein (SMN) cause spinal
muscular atrophy, a motor neuron degenerative disease. SMN is part of a complex of …

Spliceosome assembly during pre-mRNA splicing requires the correct positioning of the U1,
U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) on the precursor …

Spinal Muscular atrophy is a prevalent genetic disease caused by mutation of the SMN1
gene, which encodes the SMN protein involved in assembly of small nuclear …

The seven snRNP core proteins, Sm proteins,(SmB, SmD1, SmD2, SmD3, SmE, SmF, and
SmG), are major components of the snRNP particles that function in premRNA processing in …

The auxiliary spliceosomal protein SCNM1 contributes to recognition of nonconsensus
splice donor sites. SCNM1 was first identified as a modifier of the severity of a sodium …

Background and purpose Most spinal muscular atrophy (SMA) patients are homozygous for
survival of motor neuron 1 gene (SMN1) deletion. However, some SMA patients carry an …

Small nuclear ribonucleoprotein particles (snRNPs) are major components in spliceosomes
that play critical roles in post-transcriptional gene regulation. Among these, U1 snRNP is an …

The spliceosome plays a fundamental role in RNA metabolism by facilitating pre-RNA
splicing. To understand how this essential complex is formed, we have used protein …