Staphylococcus aureus triggers inflammation through inflammasome activation and
recruitment of neutrophils, responses that are critical for pathogen clearance but are …

Community-acquired pneumonia is the most common type of pneumonia and remains a
leading cause of morbidity and mortality worldwide. Although many different pathogens can …

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causes
infections associated with extensive tissue damage and necrosis. In vitro, human neutrophils …

RIPK3, a key mediator of necroptosis, has been implicated in the host defense against viral
infection primary in immune cells. However, gene expression analysis revealed that RIPK3 …

Sepsis is a systemic inflammatory disease causing life-threatening multi-organ dysfunction.
Accumulating evidences suggest that two forms of programmed necrosis, necroptosis and …

Common pulmonary pathogens, such as Streptococcus pneumoniae and Staphylococcus
aureus, as well as the host-adapted pathogens responsible for health care-associated …

Staphylococcus aureus USA300 strains cause a highly inflammatory necrotizing
pneumonia. The virulence of this strain has been attributed to its expression of multiple …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

Necroptosis, a form of regulated necrotic cell death, is mediated by receptor interacting
protein 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). However …

Several programmed lytic and necrotic-like cell death mechanisms have now been
uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3) …