Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future
protection of individuals and populations against SARS-CoV-2. Moreover, passively …
protection of individuals and populations against SARS-CoV-2. Moreover, passively …
Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …
variants with increased transmissibility and potential resistance, antibodies and vaccines …
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …
is unknown if antibodies elicited by infection with these variants target the same or different …
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19
vaccines and have received emergency use authorization as therapeutics. However, viral …
vaccines and have received emergency use authorization as therapeutics. However, viral …
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Z Liu, LA VanBlargan, LM Bloyet, PW Rothlauf… - BioRxiv, 2020 - biorxiv.org
Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of
most COVID-19 vaccines and being developed as therapeutics, escape mutations could …
most COVID-19 vaccines and being developed as therapeutics, escape mutations could …
[HTML][HTML] Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies
Antibodies elicited in response to infection undergo somatic mutation in germinal centers
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …
Broadly-neutralizing antibodies against emerging SARS-CoV-2 variants
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
have become a major concern in the containment of current pandemic. The variants …
have become a major concern in the containment of current pandemic. The variants …
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