Background The search for intrinsic factors, which account for a protein's capability to act as
an allergen, is ongoing. Fold stability has been identified as a molecular feature that affects …

BACKGROUND: Although antigen processing and presentation of allergens to CD4+ T
lymphocytes are key events in the pathophysiology of allergic disorders, they still remain …

Many allergens share several biophysical characteristics, including the capability to undergo
oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so …

For proteins to cause IgE-mediated allergic reactions, several common characteristics have
to be defined, including small molecular size, solubility and stability to changing pH levels …

Background Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has
been identified as the major birch pollen allergen. However, the molecular mechanisms of …

The 159 residue Bet v 1 is the major allergen from birch tree pollen. Its natural function is
unknown although it is capable of binding several types of physiologically relevant ligands …

The ability of pathogenesis-related proteins of family 10 to bind a broad spectrum of ligands
is considered to play a key role for their physiological and pathological functions. In …

Pathogenesis-related plant proteins of class-10 (PR-10) are essential for storage and
transport of small molecules. A prominent member of the PR-10 family, the major birch …

Background Allergic reactions towards the birch major pollen allergen Bet v 1 are among the
most common causes of spring pollinosis in the temperate climate zone of the Northern …

We present an analysis of the folding behavior of the 159-residue major birch pollen
allergen Bet v 1. The protein contains a water-filled channel running through it …