Osteosarcoma (OS) is the most common primary bone tumor affecting predominantly
adolescents and young adults. It accounts for about 5% of all childhood cancers. Although …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …

The overall incidence of osteosarcoma is low. However, the occurrence of osteosarcoma in
a setting of multiple primary tumours is not infrequent, although population-based incidence …

It has been difficult to identify the molecular features central to the pathogenesis of
osteosarcoma owing to a lack of understanding of the cell or origin, the absence of …

Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic
without a known genetic or environmental cause. Heritable genetic predisposition …

Although the prognosis and quality of life of patients with osteosarcoma were improved
significantly during the past decades, the pathogenesis and etiology of this disease remain …

Osteosarcoma is the most common form of bone cancer. Pivotal insight into the genes
involved in human osteosarcoma has been provided by the study of rare familial cancer …

The etiologic contribution of germline genetic variation to sporadic osteosarcoma is not well
understood. Osteosarcoma is a sentinel cancer of Li-Fraumeni syndrome (LFS), in which …

Leonard H. Wexler, MD Lee J. Helman, MD mon neoplasm after neuroblastoma and Wilms'
tumor. 2 Nearly 50 percent of cases of RMS are diagnosed in children aged five years or …

555 found in osteosarcoma tumors and cell lines39, 40. Genes other than p53 and RB1
have also been associated with osteosarcoma. High frequencies of allelic loss have been …