Background and Purpose—Animal studies suggest that nitric oxide (NO) is important in
basal cerebral blood flow (CBF) regulation and that it may mediate the vasodilatory …

Cerebral blood flow is highly sensitive to alterations in the partial pressures of O2 and CO2
(P and P, respectively) in the arterial blood. In humans, the extent to which nitric oxide (NO) …

The nitric oxide synthase (NOS) inhibitors, nitro-L-arginine, its methyl ester, and N-
monomethyl-L-arginine, have been shown to attenuate resting CBF and hypercapnia …

Nitric oxide (NO) plays a pivotal role in the regulation of peripheral vascular tone. Its role in
the regulation of cerebral vascular tone in humans remains to be elucidated. This study …

We studied the effect of nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase
(NOS) inhibitor, on the increases in cerebral blood flow (CBF) elicited by stepwise elevations …

Background and Purpose The role of nitric oxide in cerebrovascular response to changes in
Pco2 is unclear. In the present study, we assessed responses at two levels of hypercapnia in …

The importance of nitric oxide (NO) in regulating cerebral blood flow (CBF) remains
unresolved, due in part to methodological approaches, which lack a comprehensive …

We have previously demonstrated that topical cortical application of nitro-L-arginine (L-NA),
a potent inhibitor of nitric oxide (NO) synthesis, attenuates resting cerebral blood flow (CBF) …

The importance of nitric oxide (NO) for CBF variations associated with arterial carbon
dioxide changes was investigated in halothane-anesthetized rats by using an inhibitor of …

The role of nitric oxide (NO) synthesis in the cerebral hyperemic responses to hypercapnia
and hypoxia was investigated in anesthetized rats. Regional CBF (rCBF) measurements …