Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution
How do epigenetic modifications change across species and how do these modifications
affect evolution? These are fundamental questions at the forefront of our evolutionary …
affect evolution? These are fundamental questions at the forefront of our evolutionary …
Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution
DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
Genome-wide DNA methylation analyses in the brain reveal four differentially methylated regions between humans and non-human primates
Background The highly improved cognitive function is the most significant change in human
evolutionary history. Recently, several large-scale studies reported the evolutionary roles of …
evolutionary history. Recently, several large-scale studies reported the evolutionary roles of …
Methylomic trajectories across human fetal brain development
Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …
development. The importance of DNA methylation in fetal brain development is highlighted …
Adaptation of the targeted capture Methyl-Seq platform for the mouse genome identifies novel tissue-specific DNA methylation patterns of genes involved in …
Methyl-Seq was recently developed as a targeted approach to assess DNA methylation
(DNAm) at a genome-wide level in human. We adapted it for mouse and sought to examine …
(DNAm) at a genome-wide level in human. We adapted it for mouse and sought to examine …
Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices
Y Xin, B Chanrion, MM Liu, H Galfalvy, R Costa… - PloS one, 2010 - journals.plos.org
Background Emerging evidence suggests that DNA methylation plays an expansive role in
the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of …
the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of …
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
Epigenome information in mammalian brain cells reflects their developmental history,
neuronal activity, and environmental exposures. Studying the epigenetic modifications …
neuronal activity, and environmental exposures. Studying the epigenetic modifications …
Species-specific 5 mC and 5 hmC genomic landscapes indicate epigenetic contribution to human brain evolution
Human evolution from non-human primates has seen substantial change in the central
nervous system, with the molecular mechanisms underlying human brain evolution …
nervous system, with the molecular mechanisms underlying human brain evolution …
Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex
KA Perzel Mandell, AJ Price, R Wilton… - Epigenetics, 2021 - Taylor & Francis
ABSTRACT DNA methylation (DNAm) is a key epigenetic regulator of gene expression
across development. The developing prenatal brain is a highly dynamic tissue, but our …
across development. The developing prenatal brain is a highly dynamic tissue, but our …