Developmental disorders affecting speech and language are highly heritable, but very little
is currently understood about the neuromolecular mechanisms that underlie these traits …

The rise of genomic technologies has yielded exciting new routes for studying the biological
foundations of language. Researchers have begun to identify genes implicated in …

PURPOSE OF THE REVIEW: A reduced dosage of the transcription factor FOXP2 leads to
speech and language impairments probably owing to deficits in cortical and subcortical …

Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the
only known cause of developmental speech and language disorders in humans. To date …

Rare disruptions of FOXP2 have been strongly implicated in deficits in language
development. Research over the past decade has suggested a role in the formation of …

FOXP2, the first gene to have been implicated in a developmental communication disorder,
offers a unique entry point into neuromolecular mechanisms influencing human speech and …

We previously discovered that mutations of the human FOXP2 gene cause a monogenic
communication disorder, primarily characterized by difficulties in learning to make …

Childhood syndromes disturbing language development are common and display high
degrees of heritability. In most cases, the underlying genetic architecture is likely to be …

▪ Abstract A significant number of individuals have unexplained difficulties with acquiring
normal speech and language, despite adequate intelligence and environmental stimulation …