Childhood syndromes disturbing language development are common and display high
degrees of heritability. In most cases, the underlying genetic architecture is likely to be …

▪ Abstract A significant number of individuals have unexplained difficulties with acquiring
normal speech and language, despite adequate intelligence and environmental stimulation …

The human capacity to acquire sophisticated language is unmatched in the animal kingdom.
Despite the discontinuity in communicative abilities between humans and other primates …

The discovery of the FOXP2 transcription factor, and its implication in a rare severe human
speech and language disorder, has led to two decades of empirical studies focused on …

Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

Foxp subfamily genes were recently recognized to be members of the Fox gene family. Foxp
subfamily members contain a zinc finger domain and a leucine zipper motif in addition to a …

The human capacity for acquiring speech and language must derive, at least in part, from
the genome. In 2001, a study described the first case of a gene, FOXP2, which is thought to …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution due to effects on aspects of speech …

Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a
molecular window into the neurobiology of language. Individuals with FOXP2 mutations …

Highlights•Rare variants disrupting speech, in genes like FOXP2, give insight into
neurobiology of key human traits.•Neural functions of FOXP2 are being studied in human …