Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a
molecular window into the neurobiology of language. Individuals with FOXP2 mutations …
molecular window into the neurobiology of language. Individuals with FOXP2 mutations …
FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
The expression patterns of the transcription factor FOXP2 in the developing mammalian
forebrain have been described, and some studies have tested the role of this protein in the …
forebrain have been described, and some studies have tested the role of this protein in the …
FOXP transcription factors in vertebrate brain development, function, and disorders
M Co, AG Anderson, G Konopka - Wiley Interdisciplinary …, 2020 - Wiley Online Library
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …
development of several organ systems in the vertebrate body. Association of their genes …
Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder
E Sollis, SA Graham, A Vino, H Froehlich… - Human molecular …, 2016 - academic.oup.com
De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction
Humans and songbirds are two of the rare animal groups that modify their innate
vocalizations. The identification of FOXP2 as the monogenetic locus of a human speech …
vocalizations. The identification of FOXP2 as the monogenetic locus of a human speech …
Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language
In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as
the basis of an inherited speech and language disorder suffered by members of the family …
the basis of an inherited speech and language disorder suffered by members of the family …
Functional characterization of rare FOXP2 variants in neurodevelopmental disorder
SB Estruch, SA Graham, SM Chinnappa… - Journal of …, 2016 - Springer
Background Heterozygous disruption of FOXP2 causes a rare form of speech and language
impairment. Screens of the FOXP2 sequence in individuals with speech/language-related …
impairment. Screens of the FOXP2 sequence in individuals with speech/language-related …
FoxP2 regulates neurogenesis during embryonic cortical development
D Tsui, JP Vessey, H Tomita, DR Kaplan… - Journal of …, 2013 - Soc Neuroscience
The transcription factor FoxP2 has been associated with the development of human speech
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …
Functional genetic analysis of mutations implicated in a human speech and language disorder
Mutations in the FOXP2 gene cause a severe communication disorder involving speech
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …