Background Mutations in the gene encoding the transcription factor forkhead box P2
(FOXP2) result in brain developmental abnormalities, including reduced gray matter in both …

FOXP2 is the major gene associated with severe, persistent, developmental speech and
language disorders. While studies in the original family in which a FOXP2 mutation was …

Vocal communication mediated by speech and language is a uniquely human trait, and has
served an important evolutionary role in the development of our species. Deficits in speech …

The transcription factor FOXP2 has been linked to severe speech and language
impairments in humans. An analysis of the evolution of the FOXP2 gene has identified two …

Human Genetics: The Evolving Story of FOXP2: Current Biology Skip to Main Content
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FOXP2 is a forkhead transcription factor implicated in developmental verbal dyspraxia, a
human speech and language disorder. FOXP2 is expressed in complex patterns during …

Genetic disruptions of the forkhead box transcription factor FOXP2 in humans cause an
autosomal-dominant speech and language disorder. While FOXP2 expression pattern are …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution and influence aspects of speech and …

Mutations in the human FOXP2 gene cause impaired speech development and linguistic
deficits, which have been best characterised in a large pedigree called the KE family. The …

Neurodevelopmental disorders that disturb speech and language are highly heritable.
Isolation of the underlying genetic risk factors has been hampered by complexity of the …