Altered social behavior in mice carrying a cortical Foxp2 deletion
Genetic disruptions of the forkhead box transcription factor FOXP2 in humans cause an
autosomal-dominant speech and language disorder. While FOXP2 expression pattern are …
autosomal-dominant speech and language disorder. While FOXP2 expression pattern are …
Humanized Foxp2 specifically affects cortico-basal ganglia circuits
It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution and influence aspects of speech and …
have been positively selected during human evolution and influence aspects of speech and …
[HTML][HTML] An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning
Mutations in the human FOXP2 gene cause impaired speech development and linguistic
deficits, which have been best characterised in a large pedigree called the KE family. The …
deficits, which have been best characterised in a large pedigree called the KE family. The …
[HTML][HTML] Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia
Neurodevelopmental disorders that disturb speech and language are highly heritable.
Isolation of the underlying genetic risk factors has been hampered by complexity of the …
Isolation of the underlying genetic risk factors has been hampered by complexity of the …
[HTML][HTML] Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple …
L Snijders Blok, A Vino, J Den Hoed, HR Underhill… - Genetics in …, 2021 - nature.com
Purpose Heterozygous pathogenic variants in various FOXP genes cause specific
developmental disorders. The phenotype associated with heterozygous variants in FOXP4 …
developmental disorders. The phenotype associated with heterozygous variants in FOXP4 …
[HTML][HTML] Assessing the effects of common variation in the FOXP2 gene on human brain structure
The FOXP2 transcription factor is one of the most well-known genes to have been implicated
in developmental speech and language disorders. Rare mutations disrupting the function of …
in developmental speech and language disorders. Rare mutations disrupting the function of …
Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria
SJ Turner, MS Hildebrand, S Block… - American journal of …, 2013 - Wiley Online Library
Relatively little is known about the neurobiological basis of speech disorders although
genetic determinants are increasingly recognized. The first gene for primary speech disorder …
genetic determinants are increasingly recognized. The first gene for primary speech disorder …
FoxP1 orchestration of ASD-relevant signaling pathways in the striatum
DJ Araujo, AG Anderson, S Berto… - Genes & …, 2015 - genesdev.cshlp.org
Mutations in the transcription factor Forkhead box p1 (FOXP1) are causative for
neurodevelopmental disorders such as autism. However, the function of FOXP1 within the …
neurodevelopmental disorders such as autism. However, the function of FOXP1 within the …
[HTML][HTML] A functional genetic link between distinct developmental language disorders
SC Vernes, DF Newbury, BS Abrahams… - … England Journal of …, 2008 - Mass Medical Soc
Background Rare mutations affecting the FOXP2 transcription factor cause a monogenic
speech and language disorder. We hypothesized that neural pathways downstream of …
speech and language disorder. We hypothesized that neural pathways downstream of …
[HTML][HTML] De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment
Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …