Half the members of the KE family suffer from a speech and language disorder caused by a
mutation in the FOXP2 gene. We examined functional brain abnormalities associated with …

Autism spectrum disorders (ASD) is a neurodevelopmental disease with complex genetics;
however, the genes that are responsible for this disease still remain mostly unknown. Here …

Fundamental human traits, such as language and bipedalism, are associated with a range
of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is …

The molecular mechanisms driving brain development at risk in autism spectrum disorders
(ASDs) remain mostly unknown. Previous studies have implicated the transcription factor …

The ability to communicate through spoken language is the trait that best sets humans apart
from other animals, most human origins researchers say. Last year the community was …

The R553H mutation has been found in the FOXP2 gene of patients with speech-language
disorder. Foxp2 (R552H) knock-in (KI) mice exhibit poor dendritic development of Purkinje …

We genotyped a healthy population for three haplotype-tagging FOXP2 SNPs, and tested for
associations of these SNPs with strength of handedness and questionnaire-based metrics of …

Background Disruptions of the FOXP2 gene, encoding a forkhead transcription factor, are
the first known monogenic cause of a speech and language disorder. So far, mainly …

Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and
language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal …

Genome-wide high-resolution array analysis is rapidly becoming a reliable method of
diagnostic investigation in individuals with mental retardation and congenital anomalies …