Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion
S Xu, P Liu, Y Chen, Y Chen… - Proceedings of the …, 2018 - National Acad Sciences
Fundamental human traits, such as language and bipedalism, are associated with a range
of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is …
of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is …
Language fMRI abnormalities associated with FOXP2 gene mutation
Half the members of the KE family suffer from a speech and language disorder caused by a
mutation in the FOXP2 gene. We examined functional brain abnormalities associated with …
mutation in the FOXP2 gene. We examined functional brain abnormalities associated with …
Foxp1 regulation of neonatal vocalizations via cortical development
The molecular mechanisms driving brain development at risk in autism spectrum disorders
(ASDs) remain mostly unknown. Previous studies have implicated the transcription factor …
(ASDs) remain mostly unknown. Previous studies have implicated the transcription factor …
Specific expression of FOXP2 in cerebellum improves ultrasonic vocalization in heterozygous but not in homozygous Foxp2 (R552H) knock-in pups
E Fujita-Jimbo, T Momoi - Neuroscience letters, 2014 - Elsevier
The R553H mutation has been found in the FOXP2 gene of patients with speech-language
disorder. Foxp2 (R552H) knock-in (KI) mice exhibit poor dendritic development of Purkinje …
disorder. Foxp2 (R552H) knock-in (KI) mice exhibit poor dendritic development of Purkinje …
'Speech Gene'Tied to Modern Humans
M Balter - 2002 - science.org
The ability to communicate through spoken language is the trait that best sets humans apart
from other animals, most human origins researchers say. Last year the community was …
from other animals, most human origins researchers say. Last year the community was …
FOXP2 variants in 14 individuals with developmental speech and language disorders broaden the mutational and clinical spectrum
Background Disruptions of the FOXP2 gene, encoding a forkhead transcription factor, are
the first known monogenic cause of a speech and language disorder. So far, mainly …
the first known monogenic cause of a speech and language disorder. So far, mainly …
FoxP2 in Song-Learning Birds and Vocal-Learning Mammals
DM Webb, J Zhang - Journal of Heredity, 2005 - academic.oup.com
FoxP2 is the first identified gene that is specifically involved in speech and language
development in humans. Population genetic studies of FoxP2 revealed a selective sweep in …
development in humans. Population genetic studies of FoxP2 revealed a selective sweep in …
Segregating polymorphisms of FOXP2 are associated with measures of inner speech, speech fluency and strength of handedness in a healthy population
We genotyped a healthy population for three haplotype-tagging FOXP2 SNPs, and tested for
associations of these SNPs with strength of handedness and questionnaire-based metrics of …
associations of these SNPs with strength of handedness and questionnaire-based metrics of …
Striatal FoxP2 Is Actively Regulated during Songbird Sensorimotor Learning
Background Mutations in the FOXP2 transcription factor lead to language disorders with
developmental onset. Accompanying structural abnormalities in cortico-striatal circuitry …
developmental onset. Accompanying structural abnormalities in cortico-striatal circuitry …
The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers
Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and
language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal …
language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal …