FOXP2 has been identified as a gene related to speech in humans, based on rare mutations
that yield significant impairments in speech at the level of both motor performance and …

Why do some children fail to acquire speech and language skills despite adequate
environmental input and overtly normal neurological and anatomical development? It has …

Genome-wide high-resolution array analysis is rapidly becoming a reliable method of
diagnostic investigation in individuals with mental retardation and congenital anomalies …

Using a mouse model, Enard et al.(2009) show that the human form of the FOXP2 gene
increases synaptic plasticity and dendrite connectivity in the basal ganglia. These results …

FOXP1 (forkhead box protein P1) is a transcription factor involved in the development of
several tissues, including the brain. An emerging phenotype of patients with protein …

Mutations in the transcription factors FOXP1 and FOXP2 are associated with speech
impairments. FOXP1 is additionally linked to cognitive deficits, as is FOXP4. These FoxP …

Cortico-basal ganglia circuits are critical for speech and language and are implicated in
autism spectrum disorder, in which language function can be severely affected. We …

Disruptions in FOXP2, a transcription factor, are the only known monogenic cause of speech
and language impairment. We report on clinical findings for two new individuals with a …

Human FOXP2 deficiency has been identified as a cause of hereditary developmental
verbal dyspraxia. Another member of the same gene family, FOXP1, has expression patterns …

Aim To delineate the speech and language phenotype of a cohort of individuals with FOXP1‐
related disorder. Method We administered a standardized test battery to examine speech …