NK cells use NKG2D receptor to recognize 'induced-self'. In apparent violation of the
'missing-self'hypothesis, NK cells stimulated through NKG2D can lyse target cells despite …

The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …

Interaction of the activating ligand H60 with NKG2D receptor constitutes a major stimulatory
pathway for natural killer (NK) cells. The influence of inhibitory Ly49 receptors on NKG2D …

NK‐cell killing requires both the expression of activating receptor ligands and low MHC
class I expression by target cells. Here we demonstrate that the expression of any of the …

Abstract The inhibitory CD94/NKG2A and activating CD94/NKG2C killer lectin-like receptors
specific for HLA-E have been reported to be selectively expressed by discrete NK and T cell …

Mature NK cells comprise a highly diverse population of lymphocytes that express different
permutations of receptors to facilitate recognition of diseased cells and perhaps pathogens …

NK cell function is regulated by a dual receptor system, which integrates signals from
triggering receptors and MHC class I‐specific inhibitory receptors. We show here that the src …

Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of
the NKG2D tumor recognition system as well as impaired signaling by other activating NK …

Recently, it has become apparent that surface proteins commonly transfer between immune
cells in contact. Inhibitory receptors and ligands exchange between cells during NK cell …

Unlike T and B cells, NK cells lack variable, clonotypic receptors that recognize foreign
antigens. Instead, NK cells depend on conserved receptors such as NKG2D. NKG2D …