Background In mammals, the CLOCK/BMAL1 heterodimer is a key transcription factor
complex that drives the cyclic expression of clock-controlled genes involved in various …

The mammalian circadian timing system is composed of a central pacemaker in the
suprachiasmatic nucleus of the brain that synchronizes countless subsidiary oscillators in …

Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin
resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes …

A central circadian clock located in the suprachiasmatic nucleus (SCN) of the mammalian
hypothalamus entrains peripheral clocks through both neural and humoral factors. Although …

Circadian rhythms govern a wide variety of physiological and metabolic functions in many
organisms, from prokaryotes to humans. We previously reported that silent information …

Circadian rhythms are intimately linked to cellular metabolism. Specifically, the NAD+-
dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to …

The circadian rhythm generated by circadian clock underlies a molecular mechanism of
rhythmic transcriptional regulation by transcription factor BMAL1/CLOCK. Importantly, the …

Circadian rhythms regulate a wide variety of physiological and metabolic processes. The
clock machinery comprises complex transcriptional–translational feedback loops that …

Circadian locomotor output cycles kaput (CLOCK) and brain and muscle aryl hydrocarbon
receptor nuclear translocator-like protein 1 (BMAL1) are master clock genes that regulate …

The circadian clock orchestrates 24-h rhythms in physiology in most living organisms. At the
molecular level, the dogma is that circadian oscillations are based on a negative …