The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

The complement system is a critical element of the innate immune system recognizing and
killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

The immune response after brain injury is highly complex and involves both local and
systemic events at the cellular and molecular level. It is associated to a dramatic over …

The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …

The complement system is an essential effector of the humoral and cellular immunity
involved in cytolysis and immune/inflammatory responses. Complement participates in host …

The complement system provides an innate defence mechanism against pathogenic
microorganisms. Although viewed for many years as an immune-privileged organ, the …

The complement inflammatory cascade is an essential component of the phylogenetically
ancient innate immune response and is crucial to our natural ability to ward off infection …

The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

The emergence of complement as an important player in normal brain development and
pathological remodelling has come as a major surprise to most scientists working in …