Resveratrol produces substantial metabolic benefits in rodent models, and there have been
positive indications in several small human trials, yet the mechanism of action for this …

Despite resveratrol's well-documented health benefits, its mechanism of action remains
controversial. In particular, the direct molecular target of resveratrol has been elusive. Park …

The rapid increase in obesity-related diseases such as diabetes, cardiovascular disease,
and cancer is becoming a significant biomedical and socioeconomic burden. Defining the …

Resveratrol has emerged in recent years as a compound conferring strong protection
against metabolic, cardiovascular and other age-related complications, including …

Despite the promising effects of resveratrol, its efficacy in the clinic remains controversial.
We were the first group to report that the SIRT1 activator resveratrol activates AMP-activated …

Resveratrol (3, 5, 4'-trihydroxystilbene), a plant-derived polyphenol and activator of the
mamma-lian sirtuin, SIRT1, has demonstrated promising effects on glucose metabolism in …

The potential therapeutic value of resveratrol in age-related disease settings including
cancer, diabetes, and Alzheimer's has emerged from a rapidly growing body of experimental …

SIRT1 functions by regulating the modification of proteins or interacting with other proteins to
form complexes. It has been widely studied and found to play significant roles in various …

Resveratrol is a plant polyphenol capable of exerting beneficial metabolic effects which are
thought to be mediated in large by the activation of the NAD+‐dependent protein …

The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and
controversial. In this issue of Cell Metabolism, Price et al. establish a clear chemical-genetic …