Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver

B Nan, C Yang, L Li, H Ye, H Yan, M Wang… - Food and Chemical …, 2021 - Elsevier
Acrylamide (AA) in heat-processed food leads to widespread concerns due to its
hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect …

Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration

YA Samra, MF Hamed… - Journal of biochemical …, 2020 - Wiley Online Library
Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …

Allicin alleviates acrylamide-induced oxidative stress in BRL-3A cells

Y Hong, B Nan, X Wu, H Yan, Y Yuan - Life Sciences, 2019 - Elsevier
Aim Acrylamide (AA) is a common heat-generated toxicant in some food. Inhibiting its
formation with natural antioxidants is of great significance. The current study aims to …

Acrylamide induces NLRP3 inflammasome activation via oxidative stress-and endoplasmic reticulum stress-mediated MAPK pathway in HepG2 cells

N Bo, H Yilin, Y Chaoyue, L Lu, Y Yuan - Food and Chemical Toxicology, 2020 - Elsevier
Acrylamide (AA) is one of the important products of the Maillard reaction. AA hepatotoxicity is
related to inflammation, which can be indicated by the activation of NLRP3 inflammasome …

Allicin ameliorates intestinal barrier damage via microbiota-regulated short-chain fatty acids-TLR4/MyD88/NF-κB cascade response in acrylamide-induced rats

Y Yuan, L Lu, N Bo, Y Chaoyue… - Journal of agricultural …, 2021 - ACS Publications
Acrylamide (AA) is a heat-induced toxicant, which can cause severe damage to health. In
the present study, SD rats were used to investigate the potential therapeutic effects of allicin …

Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic …

D Sun, C Sun, G Qiu, L Yao, J Yu, H Al Sberi… - … Science and Pollution …, 2021 - Springer
Abstract Treatment with anti-neoplastic agents, including cyclophosphamide (CP), is
associated with several adverse reactions. Here, we distinguished the potential protective …

Rosmarinic acid attenuates acrylamide induced apoptosis of BRL-3A cells by inhibiting oxidative stress and endoplasmic reticulum stress

Z Hong, W Minghua, N Bo, Y Chaoyue… - Food and Chemical …, 2021 - Elsevier
Acrylamide (AA) is a common endogenous contaminant in food, with a complex toxicity
mechanism. The study on liver damage to experimental animals caused by AA has aroused …

Activation of the Nrf2 signaling pathway involving KLF9 plays a critical role in allicin resisting against arsenic trioxide-induced hepatotoxicity in rats

D Yang, Z Lv, H Zhang, B Liu, H Jiang, X Tan… - Biological trace element …, 2017 - Springer
Abstract Arsenic trioxide (As 2 O 3) is both the most prevalent, naturally occurring inorganic
arsenical threatening human health and an efficient therapeutic for acute promyelocytic …

Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β

X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …

[HTML][HTML] Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway

Y Yao, R Li, D Liu, L Long, N He - Ecotoxicology and Environmental Safety, 2022 - Elsevier
Rosmarinic acid (RA) is a natural polyphenol with various biological activities, such as anti-
oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to …