Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the
glucocorticoid receptor (GR) have been linked to major depressive disorder. Given the …

Prolonged and intense stress chronically increases blood concentration of glucocorticoids,
which in turn causes downregulation of glucocorticoid receptor (GR) in the central nervous …

Background Major depressive disorder is a devastating psychiatric illness that affects
approximately 17% of the population worldwide. Astrocyte dysfunction has been implicated …

Abstract Background Glucocorticoids (GCs) are steroidal hormones produced by the adrenal
cortex. A physiological‐level GCs have a crucial function in maintaining many cognitive …

Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular
mechanisms underlying their effects are unknown. We, therefore, investigated the molecular …

Glucocorticoids are stress hormones released from the adrenal cortex and their
concentration is controlled by the hypothalamic–pituitary–adrenal axis. In this study, we …

Dysfunctional glucocorticoid receptor (GR) signaling has been shown to be involved in the
pathogenesis of depressive behavior in mice and humans. In accordance with this …

Rationale The decrease of astrocyte number and hypothalamic-pituitary-adrenal (HPA) axis
overactivity are observed in individuals with major depressive disorder. Elevated levels of …

Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to
brain diseases, including mental disorders and neurodevelopmental disease. Both …

The hypothalamic-pituitary-adrenal (HPA) axis and its end-effectors glucocorticoid
hormones play central roles in the adaptive response to numerous stressors that can be …