Glucocorticoids are vital stress response hormones and facilitate stress coping. However,
sustained glucocorticoid exposure is associated with negative effects on brain. The precise …

Neurogenesis during embryonic and adult life is tightly regulated by a network of
transcriptional, growth and hormonal factors. Emerging evidence indicates that activation of …

The brain and adrenal are critical control centers that maintain body homeostasis under
basal and stress conditions, and orchestrate the body's response to stress. It is noteworthy …

Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the
ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the …

Chronic stress induces altered energy metabolism and plays important roles in the etiology
of depression, in which the glucocorticoid negative feedback is disrupted due to imbalanced …

Glucocorticoid stress hormones are powerful modulators of brain function and can affect
mood and cognitive processes. The hippocampus is a prominent glucocorticoid target and …

Glial loss in the hippocampus has been suggested as a factor in the pathogenesis of stress-
related brain disorders that are characterized by dysregulated glucocorticoid (GC) secretion …

Adolescent stress predisposes individuals to increased risk for anxiety and depression in
adulthood. The stress response is mediated by the glucocorticoid receptor (GR) via …

Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress
is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative …

In response to stressful events, the hypothalamic-pituitary-adrenal (HPA) axis is activated,
and consequently glucocorticoids are released by the adrenal gland into the blood …